Day 1

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09:00 – 09:10 – Welcome & Opening Remarks (10 min)

 

Session 1: Genetic Screening for Biological Discovery

 

09:10 – 10:40 (90 min)

• Thijn Brummelkamp, Netherlands Cancer Institute, The Netherlands (25 min)

• Silvia Domcke, University of Zurich, Switzerland (25 min)

Overcoming confounders in organoid-based CRISPR screens

• Sponsor - BD Biosciences (5 min)

• Kyla Foster, University of California San Francisco, United States (5 min)

High-content single-nuclei perturbation profiling links CRISPRi dependencies to regulatory architecture in meningioma

• Luke Gilbert, Arc Institute & University of California San Francisco, United States (25 min)

Scalable probe-based single-cell transcriptional profiling for virtual cell perturbation mapping and synthetic biology phenotyping

• Jelle Jacobs, Leuven Institute for Single Cell Omics, Belgium (5 min)

LipoGrid: A multi-omics high throughput screening platform for the systematic dissection of lipid metabolism via genetic perturbations

 

10:40 – 11:15 – Morning Coffee Break (35 min)

 

Session 2: CRISPR Screening with Single-Cell Readout

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11:15 – 12:45 (90 min)

• Christoph Bock, Center for Molecular Medicine & Medical University Vienna, Austria (25 min)

Programmed cells? Single-cell biology and cell engineering for immunity and cancer

• Laura Kida, Memorial Sloan Kettering Cancer Center, United States (5 min)

Translational perturbation screening in single-cells via multi-omic tRNA-sequencing

• Thomas Norman, Memorial Sloan Kettering Cancer Center, United States (25 min)

• Sponsor - 10x Genomics (5 min)

• Heonseok Kim, Hanyang University, South Korea (5 min)

Simultaneous single-cell measurement of engineered mutations, transcript isoforms, and transcriptomic phenotypes

• Ci Chu, Xaira Therapeutics, United States (25 min)

Towards causal biology modeling: Industrializing high-throughput Perturb-Seq at genome scale

 

12:45 – 14:00 – Lunch Break (75 min)

 

Session 3: Computational Methods and Modeling

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14:00 – 15:30 (90 min)

• Rahul Satija, New York Genome Center, United States (25 min)

• Alex Ng, GC Therapeutics, United States (5 min)

AI-guided cell fate programming trained by systematic TFome™-wide screening

• Leopold Parts, Wellcome Sanger Institute, United Kingdom (25 min)

• Sponsor - Illumina (5 min)

• Sponsor - NOMIC Bio (5 min)

• Wei Li, University of Maryland, United States (25 min)

Understanding dosage responses and building AI prediction models from single-cell perturbation datasets

 

15:30 – 16:00 – Afternoon Coffee Break (30 min)

 

Session 4: Advanced Models – iPSC & in vivo Screening

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16:00 – 17:25 (85 min)

• Xin Jin, The Scripps Research Institute, United States (25 min)

Toward a functional brain genome

• Lesly Calderon, Helmholtz Munich & Technical University of Munich, Germany (5 min)

In vivo CRISPR/Cas9 screens reveal novel regulators of B cell activation and differentiation into effector B cells

• Andreas E. Moor, ETH Zurich, Switzerland (25 min)

• Sponsor - bit.bio (5 min)

• Koen Oost, Friedrich Miescher Institute for Biomedical Research, Switzerland (25 min)

From cells to tissues: Dissecting regenerative dynamics using optical pooled screening in human colonic organoids

 

17:25 – 19:00 – Poster Session & Networking

 

19:00 – Dinner

 

Day 2

 

Session 5: CRISPR Screening for Cancer Dependencies

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09:00 – 10:30 (90 min)

• Mathew Garnett, Wellcome Sanger Institute, United Kingdom (25 min)

• Katharina Mikulik, German Cancer Research Center, Germany (5 min)

Uncovering the time- and context-dependent origins of congenital heart disease through CRISPR perturbation screening in organoids

• Francesco Iorio, Human Technopole, Italy (25 min)

• Johannes Zuber, Research Institute of Molecular Pathology, Austria (25 min)

Defining cancer dependencies in vivo

• Sponsor - Microsynth (5 min)

• Sponsor - IDT (5 min)

 

10:30 – 11:00 – Morning Coffee Break (30 min)

 

Session 6: CRISPR Screening in Primary Human Cells

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11:00 – 12:30 (90 min)

• Tilmann Bürckstümmer, Myllia Biotechnology, Austria (25 min)

Single-cell CRISPR screens in primary human myeloid cells

• Radu Rapiteanu, GSK, United Kingdom (25 min)

Target discovery through multimodal single cell CRISPR screens in primary immune cells

• Jingwen Ding, University of California San Francisco, United States (5 min)

Dissecting gene regulatory networks governing human cortical cell fate

• Sponsor - Lonza (5 min)

• Chong Li, Chinese Institute for Brain Research, China (5 min)

Decoding neurodevelopmental disorders with single-cell functional genomics in brain organoids

• Jake Taylor-King, Relation Therapeutics, United Kingdom (25 min)

Unifying spatial transcriptomics with ligand perturbation screens via biophysical models and total spatial transcriptomics workflows

 

12:30 – 14:00 – Lunch Break (90 minutes)

 

Session 7: Imaging-based CRISPR Screens

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14:00 – 15:05 (65 min)

• Samouil Farhi, Broad Institute, United States (25 min)

Simultaneous CRISPR screening and spatial -omics

• Russell Walton, Broad Institute of MIT and Harvard, United States (5 min)

Multi-modal combinatorial CRISPR screens with CROPseq-multi for high-content phenotyping of genetic interactions at scale

• Sponsor - Element Biosciences (5 min)

• Jonathan Schmid-Burgk, University of Bonn, Germany (25 min)

• Sponsor - Revvity (5 min)

 

15:05 – 15:35 – Afternoon Coffee Break (30 min)

 

Session 8: Foundation Models of Human Cells

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15:35 – 17:00 (85 min)

• Mo Lotfollahi, Welcome Sanger Institute, United Kingdom (25 min)

• Bhavya Dhaka, University College Dublin, Ireland (5 min)

HyperMap: A unified deep learning framework for predicting transcriptomic responses across diverse cell contexts

• Jin Chen, Altos Labs, United States (5 min)

Large-scale Perturb-seq in primary human cells reveals disease-reversal programs

• Yusuf Roohani, Arc Institute, United States (25 min)

Engineering cell state using artificial intelligence

• Bo Wang, Xaira Therapeutics, United States (25 min)

 

17:00 – 17:15 – Closing Remarks (15 min)